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  • Title: [The Russian gene pool: gene geography of Alu-insertions (ACE, APOA1, B65, PV92 TPA25)].
    Author: Solov'eva DS, Balanovskaia EV, Kuznetsova MA, Vasinskaia OA, Frolova SA, Pocheshkhova EA, Evseeva IV, Boldyreva MN, Balanovskiĭ OP.
    Journal: Mol Biol (Mosk); 2010; 44(3):447-55. PubMed ID: 20608168.
    Abstract:
    The analysis of five Alu insertion loci (ACE, AP4OA1, B65, PV92, TPA25) has been carried out for the first time in 10 Russian populations (1088 individuals), covered all parts of historical area of the Russian ethnos. Depending on locus, Russian populations exhibit similarity with their western (European populations) or with the eastern (populations of the Ural region) neighbors. Considering frequencies of the studied Alu-insertions, Russian gene pool exhibits low variation: average difference between populations is d = 0.007, whereas on classical markers, mtDNA and Y chromosome heterogeneity of Russian gene pool is essentially higher (0.013, 0.033 and 0.142 respectively). Therefore, this set of five Alu insertions has lower variability on the intra-ethnic level. However in inter-ethnic comparisons the clear pattern was obtained: 13 Eastern European ethnic groups formed three clusters, according with their historical and geographical position--East Slavic, Caucasian and South Ural clusters. The obtained data confirms efficiency of using Alu insertions for studying genetic differentiation and history of a gene pool of the Eastern European populations.
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