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  • Title: Studies on the influence of monoamines on the cerebrovascular response to arterial hypoxia.
    Author: Ekström-Jodal B, Elfverson J, von Essen C.
    Journal: Acta Neurol Scand; 1978 Feb; 57(2):159-70. PubMed ID: 206090.
    Abstract:
    The cerebrovascular response to arterial hypoxia was studied during blockade of the vascular dopamine receptors and during alpha-adrenergic receptor stimulation and blockade in anaesthetized dogs. Dopamine receptor blockade with pimozide or haloperidol invariably decreased the degree of hypoxic vasodilatation in the brain pointing to a functional role of dopamine in this situation. Alpha-receptor blockade did not change the response, while stimulation of these receptors decreased the dilatory response even in deep arterial hypoxia.
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