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  • Title: [Liver cell carcinoma associated with oral contraceptives (author's transl)].
    Author: Leclère J, Meot B, Marchal F, Mizrahi R, Collard F, Rauber G, Hartemann P.
    Journal: Ann Endocrinol (Paris); 1977; 38(6):361-2. PubMed ID: 206178.
    Abstract:
    A new case report of primary malignant hepatic tumor during a long term oral contraception is presented. A direct role of contraceptives drugs cannot be claimed because of little cases reported. Nevertheless, appearance of carcinogenic compounds in predisposed women may be evoked. The article describes the case of a 42 year old woman who died of liver cell carcinoma; the woman had been on oral contraceptives (OCs) for 10 years. The association between OCs and liver cancer is being reported more and more frequently. Still, it is not clear exactly which is the mechanism that causes the malignant tumor. If coincidence and preexisting tumor are ruled out, it is possible that OCs, diminishing biliar excretion, help the accumulation of carcinogenetic substances.
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