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  • Title: Tandem asymmetric Michael reaction-intramolecular Michael addition. An easy entry to chiral fluorinated 1,4-dihydropyridines.
    Author: Fustero S, Catalán S, Sánchez-Roselló M, Simón-Fuentes A, del Pozo C.
    Journal: Org Lett; 2010 Aug 06; 12(15):3484-7. PubMed ID: 20617822.
    Abstract:
    A novel one-pot tandem asymmetric Hantzsch-type process has been employed to generate fluorinated 1,4-dihydropyridines (1,4-DHPs) as single diastereoisomers. It involves the condensation of (R)-(+)-allyl p-tolyl sulfoxide, fluorinated nitriles, and alkyl propiolates, giving access to a new family of enantiomerically pure fluorine-containing 1,4-DHPs.
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