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  • Title: Glutamate and GABA in the balance: convergent pathways sustain seizures during status epilepticus.
    Author: Naylor DE.
    Journal: Epilepsia; 2010 Jul; 51 Suppl 3():106-9. PubMed ID: 20618413.
    Abstract:
    Seizures rapidly become self-sustaining and pharmacoresistant to benzodiazepines during status epilepticus (SE). A decrease in the number of postsynaptic gamma-aminobutyric acid (GABA)(A) receptors with SE causes a loss of synaptic inhibition, whereas increases in postsynaptic glutamatergic receptors further upset the balance between excitation and inhibition. Although extracellular GABA levels may increase during SE and contribute to postsynaptic GABA(A) receptor desensitization, other pathways involving glutamatergic activation ultimately may be responsible for the persistent down-regulation of postsynaptic GABA(A) receptors and erosion of synaptic inhibition.
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