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  • Title: Binding of several benzodiazepines to bovine serum albumin: Fluorescence study.
    Author: Machicote RG, Pacheco ME, Bruzzone L.
    Journal: Spectrochim Acta A Mol Biomol Spectrosc; 2010 Oct 01; 77(2):466-72. PubMed ID: 20621550.
    Abstract:
    The interactions of lorazepam, oxazepam and bromazepam with bovine serum albumin (BSA) were studied by fluorescence spectrometry. The Stern-Volmer quenching constants and corresponding thermodynamic parameters DeltaH, DeltaG and DeltaS were calculated. The binding constants and the number of binding sites were also investigated. The distances between the donor (BSA) and the acceptors (benzodiazepines) were obtained according to fluorescence resonance energy transfer and conformational changes of BSA were observed from synchronous fluorescence spectra.
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