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  • Title: Design and synthesis of 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles and pyrazolo[3,4-b]pyridines for Aurora-A kinase inhibitors.
    Author: Shi J, Xu G, Zhu W, Ye H, Yang S, Luo Y, Han J, Yang J, Li R, Wei Y, Chen L.
    Journal: Bioorg Med Chem Lett; 2010 Jul 15; 20(14):4273-8. PubMed ID: 20621733.
    Abstract:
    Two series of 3-aminopyrazole compounds including 24 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles and 16 pyrazolo[3,4-b]pyridines were synthesized and evaluated against HCT116, A549, and A2780 tumor cell lines. Among them, three compounds were found to have the ideal anti-proliferative activities in vitro. Docking experiments showed that the novel pyrazolo[3,4-b]pyridines share the similar interaction mode with Aurora-A kinase as PHA739358.
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