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  • Title: Thermo-responsive Mn-Zn ferrite/poly(N,N'-isopropyl acrylamide-co-N-hydroxymethylacrylamide) core/shell nanocomposites for drug-delivery systems.
    Author: Yang C, Jie R, Jianbo L, Yan L.
    Journal: J Biomater Sci Polym Ed; 2011; 22(11):1473-86. PubMed ID: 20626931.
    Abstract:
    A kind of thermo-sensitive core/shell nanoparticles (Mn-Zn ferrite/poly(N,N'-isopropylacrylamide-co-N-hydroxymethylacrylamide)) has been designed in this work. By using the surface initiated method, a thermoresponsive co-polymer composed of N,N'-isopropylacrylamide (NIPAAm) and N-hydroxymethylacrylamide (HMAAm) was grafted from ferrite core. The nanoparticles obtained were characterized by FT-IR, XRD, TGA, HRTEM and DLS. The HRTEM observation showed a clear contrast between an ordered crystalline core and a light amorphous polymeric coating. DLS results confirmed the temperature sensitivity of the nanoparticles. In vitro hyperthermia showed well-controlled self-heating properties, indicating that the nanoparticles could potentially be used as an anticancer drug carrier in the biomedical field.
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