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  • Title: Analysis and stability study of temozolomide using capillary electrophoresis.
    Author: Andrasi M, Bustos R, Gaspar A, Gomez FA, Klekner A.
    Journal: J Chromatogr B Analyt Technol Biomed Life Sci; 2010 Jul 01; 878(21):1801-8. PubMed ID: 20627825.
    Abstract:
    The applicability of micellar electrokinetic capillary chromatography (MEKC) for the analysis of temozolomide (TMZ) and its degradants, 3-methyl-(triazen-1-yl)imidazole-4-carboxamide (MTIC) and 5-amino-imidazole-4-carboxamide (AIC) has been studied. Using short-end injection, the analysis of TMZ and its degradants could be performed within 1.2 min. The obtained precision of migration times was better than 1.6 RSD%, and the limit of quantitation (LOQ) was 0.31-0.93 microg/mL. The therapeutic concentration of TMZ in blood samples can be determined after direct sample injection and conventional on-capillary UV detection. The proposed MEKC method was applied to study the stability of TMZ in water and serum at different pH values. It was established that the half-life of the TMZ in vitro serum at room temperature was 33 min, close to the half-life (28 min) obtained in water at pH 7.9.
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