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  • Title: Choleretic effect of picroliv, the hepatoprotective principle of Picrorhiza kurroa.
    Author: Shukla B, Visen PK, Patnaik GK, Dhawan BN.
    Journal: Planta Med; 1991 Feb; 57(1):29-33. PubMed ID: 2062954.
    Abstract:
    Picroliv, the hepatoprotective principle of the plant Picrorhiza kurroa, showed a dose-dependent (1.5-12 mg/kg x 7) choleretic effect in conscious rats and anaesthetised guinea pigs. It also possessed a marked anticholestatic effect against paracetamol- and ethynylestradiol-induced cholestasis. It antagonised the changes in bile volume as well as the contents (bile salts and bile acids). Silymarin, a known hepatoprotective agent, was tested simultaneously for comparison. Picroliv was found to be a more potent choleretic and anticholestatic agent than silymarin.
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