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  • Title: Hypervalent iodine(III) mediated synthesis of novel unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles as antibacterial and antifungal agents.
    Author: Prakash O, Kumar M, Kumar R, Sharma C, Aneja KR.
    Journal: Eur J Med Chem; 2010 Sep; 45(9):4252-7. PubMed ID: 20630627.
    Abstract:
    A series of novel 2,5-disubstituted 1,3,4-oxadiazoles 4 have been conveniently synthesized by oxidative cyclization of pyrazolylaldehyde N-acylhydrazones 3 promoted by iodobenzene diacetate under mild conditions (11 examples, up to 92% isolated yields). All the eleven compounds were tested in vitro for their antibacterial activity against gram-positive bacteria namely, Staphylococcus aureus, Bacillus subtilis and two gram-negative bacteria namely, Escherichia coli and Pseudomonas aeruginosa. All the synthesized compounds were also tested for their inhibitory action against two strains of fungus.
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