These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Mixed micellization of antidepressant drug amitriptyline hydrochloride with cationic surfactants.
    Author: Kabir-ud-Din, Khan AB, Naqvi AZ.
    Journal: Colloids Surf B Biointerfaces; 2010 Oct 15; 80(2):206-12. PubMed ID: 20634044.
    Abstract:
    The surface tension measurements have been carried out on aqueous solutions of antidepressant drug amitriptyline hydrochloride with six cationic surfactants (decyl-, dodecyl-, tetradecyl-, cetyltrimethylammonium bromide, cetylpyridinium bromide and cetylpyridinium chloride) at different mole fractions to study the surface and micellar properties at the interface as well as in the micelles. The properties studied include critical micelle concentration (cmc), Gibbs surface excess (Gamma(max)), minimum head group area at the air/water interface (A(min)), free energy of micellization (DeltaG(m)( composite function)), and standard Gibbs energy of adsorption (DeltaG(ads)( composite function)), while synergistic behavior of drug-surfactant binary mixtures was analysed using Clint's and Rubingh's models. Deviations of cmc from cmc(*) and X(1)(m) from X(1)(ideal) indicate the synergistic behavior (i.e., non-ideal behavior) for the drug-surfactant binary mixtures. The values of interaction parameters beta and activity coefficients f(1) and f(2) (for both, in mixed monolayer as well as in mixed micelles) also indicate the synergistic behavior. The excess free energy (DeltaG(ex)) for the drug-surfactant binary mixtures explains stability of mixed micelles in comparison to micelles of pure drug and variation with alkyl chain length of surfactants.
    [Abstract] [Full Text] [Related] [New Search]