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  • Title: Plasma thiobarbituric acid reactive substances a predictive marker of cerebral ischemia in patients at high risk?
    Author: Alessandri C, Germani M, Censi C, Rudelli G, Iuliano L, Servi M, Ghiselli A, Violi F.
    Journal: Acta Neurol Scand; 1991 May; 83(5):323-7. PubMed ID: 2063655.
    Abstract:
    The clinical meaning of high values of blood lipid peroxides, assessed as thiobarbituric acid reactive substances (TBA-RS), was investigated in 19 selected high risk patients with transient ischemic attacks (TIA). Patients were checked every 3-6 months and followed-up for 3 years. 8 patients experienced further vascular episodes, 4 having minor stroke and 4 TIA; one of the latter died from myocardial infarction. Unlike blood cholesterol and glucose. TBA-RS values discriminated patients with vascular episodes: they, indeed, showed significant higher values of TBA-RS. Discriminant analysis further indicated that TBA-RS levels differentiate patients with and without vascular accidents, suggesting that high blood values of lipid peroxides could represent a predictive sign of vascular ischemia.
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