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  • Title: Aromatic acid metabolites of Escherichia coli K-12 can induce the marRAB operon.
    Author: Chubiz LM, Rao CV.
    Journal: J Bacteriol; 2010 Sep; 192(18):4786-9. PubMed ID: 20639340.
    Abstract:
    MarR is a key regulator of the marRAB operon involved in antibiotic resistance and solvent stress tolerance in Escherichia coli. We show that two metabolic intermediates, 2,3-dihydroxybenzoate and anthranilate, involved in enterobactin and tryptophan biosynthesis, respectively, can activate marRAB transcription. We also found that a third intermediate involved in ubiquinone biosynthesis, 4-hydroxybenzoate, activates marRAB transcription in the absence of TolC. Of the three, however, only 2,3-dihydroxybenzoate directly binds MarR and affects its activity.
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