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  • Title: Two new lignans from the roots of Pulsatilla koreana.
    Author: Cuong TD, Hung TM, Kim JC, Huh JI, Kwack SJ, Kang TS, Kim JH, Jang HS, Choi JS, Lee HK, Bae K, Min BS.
    Journal: Planta Med; 2011 Jan; 77(1):66-9. PubMed ID: 20645248.
    Abstract:
    Two new lignans, (2 R,3 R)-2 β-(4''-hydroxy-3''-methoxybenzyl)-3 α-(4'-hydroxy-3'-methoxybenzyl)-γ-butyrolactone 2-O-( β-D-glucopyranoside) (1) and (1 S,2 R,3 S)-dimethyl-1,2,3,4-tetrahydro-3,6,7-trihydroxy-1-(3',4'-dihydroxyphenyl)naphthalene-2,3-dicarboxylate (2) together with nine known compounds (3-11) were isolated from the ethyl acetate fraction of the roots of Pulsatilla koreana. Their chemical structures were established based on physicochemical and spectroscopic data analyses. All isolates were investigated for their inhibition effects against the classical pathway of the complement system. Among them, compound 6 showed significant inhibitory activity with an IC (50) value of 75.9 µM, compounds 8 and 9 had moderate effects with IC (50) values of 182.2 and 166.5 µM, respectively.
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