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  • Title: Successful resuscitation following ropivacaine-induced systemic toxicity in a neonate.
    Author: Hübler M, Gäbler R, Ehm B, Oertel R, Gama de Abreu M, Koch T.
    Journal: Anaesthesia; 2010 Nov; 65(11):1137-40. PubMed ID: 20645946.
    Abstract:
    A 5-week-old preterm infant was scheduled for inguinal hernia repair. Following induction of general anaesthesia, 10 mg.kg(-1) ropivacaine was injected, accidently, into the caudal space. The infant developed cardiac depression with bradycardia (minimum heart rate 50 beats.min(-1) ), elevated T waves and widening of QRS complexes. Resuscitation by means of external chest compression, intravenous adrenaline and fluid administration was successful. Ropivacaine serum concentrations were obtained at three time points yielding a peak level of 6 μg.ml(-1) 20 min after caudal injection.
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