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  • Title: An uncommon complementary isochromosome of 46,XY, i(9)(p10),i(9)(q10) in an infertile oligoasthenoteratozoospermic man.
    Author: Guvendag Guven ES, Dilbaz S, Ceylaner S, Acar H, Cinar O, Ozdegirmenci O, Karcaaltincaba D.
    Journal: Fertil Steril; 2011 Jan; 95(1):290.e5-8. PubMed ID: 20646692.
    Abstract:
    OBJECTIVE: To report a rare case of male infertility associated with oligoasthenoteratozoospermia and complementary isochromosome 46 XY, i(9)(p10),i(9)(q10). DESIGN: Case report. SETTING: Reference hospital. PATIENT(S): Infertile oligoastenozoospermic man with complementary isochromosome 46,XY, i(9)(p10),i(9)(q10). INTERVENTION(S): Peripheral blood lymphocytes obtained for karyotyping, and florescence in situ hybridization (FISH) analysis for gonadal mosaicism in ejaculated spermatozoa. MAIN OUTCOME MEASURE(S): Physical examination, semen analysis, GBG banding, and FISH procedure. RESULT(S): The semen analysis revealed oligoasthenoteratozoospermia. The lymphocytic karyotype detected a complementary isochromosome 46,XY, i(9)(p10),i(9)(q10), and the FISH procedure showed abnormal sperm. CONCLUSION(S): This the first report of oligoasthenoteratozoospermia associated with complementary isochromosome 46,XY, i(9)(p10),i(9)(q10).
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