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  • Title: Age-related tissue distribution of swine Torque teno sus virus 1 and 2.
    Author: Aramouni M, Segalés J, Cortey M, Kekarainen T.
    Journal: Vet Microbiol; 2010 Dec 15; 146(3-4):350-3. PubMed ID: 20646878.
    Abstract:
    Torque teno viruses (TTVs) are small, non-enveloped viruses with a circular single-stranded DNA genome, belonging to the family Anelloviridae. In swine, two genetically distinct species have been identified, Torque teno sus virus 1 (TTSuV1) and 2 (TTSuV2). The aim of the present work was to study the tissue distribution of TTSuV1 and TTSuV2 in pigs of different ages, including foetuses at the second and last thirds of gestation, and animals at 5 days and 5, 15 and 24 weeks of age. Investigated tissues included brain, lung, mediastinal and mesenteric lymph nodes, heart, liver, spleen, kidney and bone marrow. Viral DNA from tissue extractions were tested by a comparative PCR for the presence of TTSuVs. Overall, TTSuV1 and TTSuV2 species were found in all tissues tested, with variations depending on age, and following similar infection dynamics in all tissues, increasing progressively in prevalence and virus load over time. The highest prevalence was found at 5 weeks of age and maintained afterwards, and the highest loads of virus in the different tissues were seen in the oldest animals (15 and 24 weeks of age). No animals were negative to TTV, including foetuses. In conclusion, the present study indicated that swine TTSuV1 and TTSuV2 can be found virtually in all body tissues of the pig. Both swine TTV species were present in high levels in almost all older animals, while viral negative tissues were only found in 5-week-old and 5-day-old pigs, and foetuses.
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