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  • Title: Successful treatment of dwarfism secondary to long-term steroid therapy in steroid-dependent nephrotic syndrome.
    Author: Sun L, Chen D, Zhao X, Xu C, Mei C.
    Journal: Intern Med; 2010; 49(14):1417-21. PubMed ID: 20647659.
    Abstract:
    Prolonged steroid therapy is generally used for steroid-dependent nephrotic syndrome in pediatric patients. However, dwarfism secondary to a long-term regimen and its successful reverse is rarely reported. The underlying mechanism of dwarfism is still poorly understood, as both long-term steroid use and nephrotic syndrome may interact or independently interfere with the process of growth. Here, we present a 17-year-old patient with dwarfism and steroid-dependent nephrotic syndrome and the successful treatment by recombinant human growth factor and cyclosporine A with withdrawal of steroid. We also briefly review the current understanding and the management of dwarfism in pediatric patients with nephrotic syndrome.
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