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  • Title: A graphene-enhanced molecular beacon for homogeneous DNA detection.
    Author: Li F, Huang Y, Yang Q, Zhong Z, Li D, Wang L, Song S, Fan C.
    Journal: Nanoscale; 2010 Jun; 2(6):1021-6. PubMed ID: 20648302.
    Abstract:
    In this work, we report the design of a novel graphene-based molecular beacon (MB) that could sensitively and selectively detect specific DNA sequences. The ability of water-soluble graphene oxide (GO) to differentiated hairpin and dsDNA offered a new approach to detect DNA. We found that the background fluorescence of MB was significantly suppressed in the presence of GO, which increased the signal-to-background ratio, hence the sensitivity. Moreover, the single-mismatch differentiation ability of hairpin DNA was maintained, leading to high selectivity of this new method.
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