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  • Title: A chromosomal translocation causing overproduction of iso-2-cytochrome c in yeast.
    Author: Sherman F, Helms C.
    Journal: Genetics; 1978 Apr; 88(4 Pt 1):689-707. PubMed ID: 206486.
    Abstract:
    The CYC7-1 mutation in the yeast Saccharomyces cerevisiae causes the production of approximately 30 times the normal amount of iso-2-cytochrome c. Genetic analysis established that the CYC7-1 mutation is a reciprocal translocation involving the left arm of chromosome V and the right arm of chromosome XVI. The chromosome V arm was broken adjacent to the gene CYC7, which determines the primary structure of iso-2-cytochrome c, and this fragment containing the CYC7 gene was joined to the segment of chromosome XVI. It appears as though the elevation of iso-2-cytochrome c is caused by an abnormal controlling region adjacent to the structural region of the CYC7 gene.
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