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  • Title: Electrochemical investigations of cytochrome P450.
    Author: Shumyantseva VV, Bulko TV, Suprun EV, Chalenko YM, Vagin MY, Rudakov YO, Shatskaya MA, Archakov AI.
    Journal: Biochim Biophys Acta; 2011 Jan; 1814(1):94-101. PubMed ID: 20650335.
    Abstract:
    In this paper we summarized our experimental data on the electrochemical reduction of cytochrome P450. Electrode/cytochrome P450 systems were analyzed in terms of the mechanisms underlying P450-catalyzed reactions. Bioelectrocatalysis-based screening of potential substrates or inhibitors of cytochrome P450, stoichiometry of the electrocatalytic cycle, redox thermodynamics and the peroxide shunt pathway were described. Characteristics, performance and potential application of cytochrome P450-electrodes are discussed.
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