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  • Title: [Correlation of IL-1beta-511 and IL-1RN VNTR gene polymorphism to coronary heart disease: a meta-analysis].
    Author: Chen F, Cheng W.
    Journal: Nan Fang Yi Ke Da Xue Xue Bao; 2010 Jul; 30(7):1635-8. PubMed ID: 20650788.
    Abstract:
    OBJECTIVE: To evaluate the correlation between the gene polymorphism of IL-1beta-511 or IL-1RN VNTR and the risk of coronary heart disease (CHD). METHODS: The patient-control studies on the association of IL-1=-511 or IL-1RN VNTR gene polymorphism with the risk of CHD were searched according to the inclusion criteria. Heterogeneity tests were conducted for the data from each study before Meta-analysis. RESULTS: For the 7 studies addressing the correlation between IL-1beta-511 polymorphism and the susceptibility of CHD, the pooled odds ratio was about 1.04 with 95% CI of 0.93-1.18 (Z=0.71, P=0.48). For the 5 studies of the correlation between IL-1RN VNTR polymorphism and the susceptibility of CHD, the pooled odds ratio was about 1.01 and the 95% CI was 0.78-1.17 (Z=0.08, P=0.93). CONCLUSION: The gene polymorphism of IL-1beta-511 or IL-1RN VNTR has no correlation to the susceptibility of CHD, but is associated with in the disease development and clinical phenotype.
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