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  • Title: Rhodamine-based chemosensor for Hg(2+) in aqueous solution with a broad pH range and its application in live cell imaging.
    Author: Zhao Y, Sun Y, Lv X, Liu Y, Chen M, Guo W.
    Journal: Org Biomol Chem; 2010 Sep 21; 8(18):4143-7. PubMed ID: 20652184.
    Abstract:
    A new fluorescent probe, rhodamine B derivative (1) bearing an 8-hydroxyquinoline group, was synthesized and displayed highly selective and sensitive Hg(2+)-amplified absorbance and fluorescence emission above 500 nm in aqueous solution with a broad pH range 4-9. It was found that mercury ions coordinate reversibly to 1 and the spirolactam ring of 1 was opened, forming a 1 : 1 metal-ligand complex. Furthermore, this sensor was applied for in vivo imaging in HeLa cells to confirm that 1 can be used as a fluorescent probe for monitoring Hg(2+) in living cells.
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