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  • Title: [Pathological characteristics and clinical significance of macrochilia secondary to venular malformation].
    Author: Wang W, Lin XX, Ma G, Li W, Hu XJ, Chen H.
    Journal: Zhonghua Kou Qiang Yi Xue Za Zhi; 2010 Apr; 45(4):211-3. PubMed ID: 20654195.
    Abstract:
    OBJECTIVE: To analyze the histologic characteristics of macrochilia secondary to port-wine stain and to elucidate the possible mechanism. METHODS: Twenty-one cases of macrochilia secondary to venular malformation were included and the histology of the lesions was observed by light microscope. RESULTS: Histological examination revealed vascular abnormalities and a number of widely distributed hamartomatous changes in macrochilia secondary to venular malformation. The average vessel diameter is (39.8 +/- 15.7) microm. The degree of hamartomatous change: mild (1 case), moderate (7 cases) and severe (13 cases). CONCLUSIONS: The complex hamartomatous changes suggest a genetically determined, multilineage developmental field defect in the pathogenesis of venular malformation.
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