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  • Title: Resting brain connectivity: changes during the progress of Alzheimer disease.
    Author: Zhang HY, Wang SJ, Liu B, Ma ZL, Yang M, Zhang ZJ, Teng GJ.
    Journal: Radiology; 2010 Aug; 256(2):598-606. PubMed ID: 20656843.
    Abstract:
    PURPOSE: To investigate alterations in functional connectivity in the resting brain networks in healthy elderly volunteers and patients with mild, moderate, or severe Alzheimer Disease (AD). MATERIALS AND METHODS: This study was approved by the institutional ethics committee, and informed consent was obtained. Forty-six patients with AD and 16 healthy elderly volunteers were prospectively examined. Resting-state functional magnetic resonance imaging was used to detect alterations in posterior cingulate cortex (PCC) functional connectivity through a comparison of the healthy control group with three separate AD groups-mild, moderate, and severe AD. A temporal correlation method was used to obtain PCC connectivity maps. RESULTS: Dissociated functional connectivity between the PCC and a set of regions, including the visual cortices bilaterally, the inferior temporal cortex, the hippocampus, and especially the medial prefrontal cortex and the precuneus and/or cuneus, was observed in all AD groups. The disruption of connectivity intensified as the stage of AD progression increased. There were also regions that exhibited increased connectivity; these regions extended from left lateralized frontoparietal regions and spread to bilateral frontoparietal regions along with AD progression. CONCLUSION: Changes in PCC functional connectivity comprised bidirectional alterations in the resting networks in AD-affected brains, and the impaired resting functional connectivity seemed to change with AD progression. Therefore, alterations in functional connectivity in the default mode network might play a role in the progression of AD.
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