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  • Title: Faster healing of venous ulcers with crystacide: a clinical and microcirculatory 8-week registry study.
    Author: Cesarone MR, Belcaro G, Errichi BM, Ricci A, Bavera P, Ippolito E, Dugall M.
    Journal: Panminerva Med; 2010 Jun; 52(2 Suppl 1):11-4. PubMed ID: 20657528.
    Abstract:
    AIM: This registry evaluated the result of treatment with Crystacide in 73 patients with chronic venous insufficiency (CVI) and ulcerations. The local application of a hydrogen peroxide cream (Crystacide, Sandoz) onto the skin was evaluated with clinical and microcirculatory parameters. After briefing, one group used Crystacide and standard management for ulcers, including compression. A comparable group that did not use Crystacide was also evaluated. METHODS: Laser Doppler flowmetry (LDF) was used to measure skin perfusion in association with skin TcP02 and TcPCO2. Crystacide was applied around and on the ulcer area for a period between 6 and 9 weeks (with a target time of observation of 8 weeks). RESULTS: Treatment with Crystacide was more effective. The increased skin flux at inclusion (indicating venus hypertension and microangiopathy) decreased in both groups (improving); TcO2 was increased (P<0.05) and TcCO2 was decreased (P<0.05) in both groups. However, changes in the microcirculatory parameters were significantly larger in the Crystacide group. The average ulcer area was significantly smaller at the average target time of 8 weeks in the Crystacide group in comparison with controls (P<0.05). In the Crystacide group 64.86% of the ulcers were completely healed at 8 weeks versus 38.88% in controls. The difference (+25.98%) in the treatment group is significant (P<0.002). CONCLUSION: Local treatment with Crystacide improves the healing of venous ulcerations by improving skin perfusion.
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