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  • Title: Proton translocating ATPase mediated fungicidal activity of eugenol and thymol.
    Author: Ahmad A, Khan A, Yousuf S, Khan LA, Manzoor N.
    Journal: Fitoterapia; 2010 Dec; 81(8):1157-62. PubMed ID: 20659536.
    Abstract:
    Eugenol (1) and thymol (2) exhibit excellent fungicidal activity against pathogenic yeasts, including isolates resistant to azoles. The rapid irreversible action of compound-1 and compound 2 on fungal cells suggested a membrane-located target for their action. We investigated their effect on H(+)-ATPase mediated H(+)-pumping by various Candida species. Both compounds inhibit H(+)-ATPase activity at their respective MIC values--500 and 100 μg/ml. Glucose stimulated H(+)-extrusion was also inhibited significantly by compound 1 and compound 2. Inhibition of H(+)-ATPase leads to intracellular acidification and cell death. Inhibition of cell growth and H(+)-efflux by test compounds suggests that their antifungal properties are related to their inhibitory effects on H(+)-ATPase.
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