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  • Title: A randomized double-blind, positive-control trial of topical thalidomide in erosive oral lichen planus.
    Author: Wu Y, Zhou G, Zeng H, Xiong CR, Lin M, Zhou HM.
    Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2010 Aug; 110(2):188-95. PubMed ID: 20659697.
    Abstract:
    OBJECTIVE: The objective of this study was to evaluate the short-term efficacy and safety of topical thalidomide for erosive oral lichen planes (OLP) in a prospective randomized, positive-control, double-blind clinical trial. STUDY DESIGN: Sixty-nine patients with erosive OLP received thalidomide 1% paste (n = 37) or dexamethasone 0.043% paste (n = 32) for 1 week. Patients without erosions after initial 1-week treatment were followed for recurrence, whereas those with ongoing erosions received an additional 3-week treatment. Outcome measures included size of erosive area, visual analog scale (VAS) scores, 3-month recurrence rates, and adverse effects at 1 year. RESULTS: After 1-week application, both groups showed significant reductions in erosive areas and VAS scores (P < .001). Complete healing occurred in 18 (54.5%) of 33 thalidomide-treated and 17 (56.7%) of 30 dexamethasone-treated patients. Erosive area size (P = .420) and VAS scores (P = .498) were similar between groups. After 1 month of treatment, 24 patients receiving thalidomide (66.7%) and 22 receiving dexamethasone (73.3%) fully healed. There was no difference between groups in recurrence at the 3-month follow-up. Only 2 patients in each group experienced discomfort with treatment, and no adverse reactions were observed over 1 year of follow-up. CONCLUSION: Topical thalidomide appears as effective as dexamethasone for erosive OLP.
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