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  • Title: Synthesis and preliminary characterization of sulfamethazine-theophylline co-crystal.
    Author: Lu J, Rohani S.
    Journal: J Pharm Sci; 2010 Sep; 99(9):4042-7. PubMed ID: 20665847.
    Abstract:
    Co-crystals containing active pharmaceutical ingredients (APIs) represent a new type of pharmaceutical materials. In this work, sulfamethazine (STH) and theophylline (TP) were employed as the co-crystal formers. Neat cogrinding, solvent-drop cogrinding and slow evaporation were applied to synthesize the sulfamethazine-theophylline co-crystal (hereafter STH-TP co-crystal). The co-crystalline phase was characterized by DSC, TGA, Raman, PXRD, and dynamic vapor sorption (DVS) techniques. The STH-TP co-crystal structure was determined from single crystal X-ray diffraction data. The results show that, the STH-TP co-crystal, obtained in a 2:1 molar ratio of sulfamethazine and theophylline only by slow evaporation, possesses unique thermal, spectroscopic, and X-ray diffraction properties. Besides, in the STH-TP co-crystal, the sulfamethazine molecules form a dimer through the intermolecular hydrogen bonding (O ... H -- N), and two intermolecular hydrogen bonds (O ... H -- N and N ... H -- N) keep the theophylline attached the dimer.
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