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  • Title: Efficacy of topical cyanoacrylates compared to topical silicone gel in the treatment of hypertrophic scars.
    Author: Scuderi N, Dessy LA, Mazzocchi M, Chiummariello S, Onesti MG.
    Journal: In Vivo; 2010; 24(4):591-7. PubMed ID: 20668330.
    Abstract:
    AIM: The effectiveness of cyanoacrylates compared to silicone gel in improving healing of hypertrophic scars was evaluated. PATIENTS AND METHODS: Patients presenting hypertrophic scars 6 to 24 months old were enrolled. Asymmetrical scars were treated with cyanoacrylates, linear scars were divided in two parts, one treated with cyanoacrylates, the other with silicone gel. For 3 months, cyanoacrylates were applied every 3-5 days, silicone gel twice a day. Patients' and external observers' assessments were recorded over one year, and photographic records taken. Objective evaluations included width, length and elevation measurements. Statistical significance of parameter modifications was analysed with the Wilcoxon test. RESULTS: A total of 150 patients were enrolled. Positive effects of both tested products were observed without major adverse effects, achieving final scars of better quality. Scar elevation was reduced significantly for both tested products, but apparently more for topical cyanoacrylates. CONCLUSION: Cyanoacrylates have a positive effect on pathological scars at least comparable to that of silicone gel.
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