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  • Title: Anti-obesity effect of Morus bombycis root extract: anti-lipase activity and lipolytic effect.
    Author: Kim YS, Lee YM, Kim H, Kim J, Jang DS, Kim JH, Kim JS.
    Journal: J Ethnopharmacol; 2010 Aug 09; 130(3):621-4. PubMed ID: 20669373.
    Abstract:
    AIM OF THE STUDY: This study evaluated anti-obesity effect of the ethanolic extract of Morus bombycis root on lipase activity and lipolysis in adipocytes and adipose tissues. MATERIALS AND METHODS: Lipase (triacylgycerol acylhydrolase, EC 3.1.1.3) activity was determined by measuring the hydrolysis of p-nitrophenyl butyrate to p-nitrophenol at 405 nm. Lipolytic effects were assayed in fully differentiated 3T3-L1 adipocytes and adipose tissues. In vitro, phosphodiesterase (PDE) activity was also measured. RESULTS: Morus bombycis root extract exhibited strong anti-lipase activity, with an IC50 value of 2.07 microg/mL.In differentiated adipocytes and adipose tissues, the extract increased lipolytic effects such as decreased intracellular triglyceride and the release of glycerol. Further, the extract inhibited PDE activity in a dose-dependent manner. CONCLUSION: The present study suggests that Morus bombycis root extract might be of therapeutic interest with respect to the treatment of obesity.
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