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  • Title: Facile dimer synthesis for DNA-binding polyamide ligands.
    Author: Wetzler M, Wemmer DE.
    Journal: Org Lett; 2010 Aug 06; 12(15):3488-90. PubMed ID: 20670013.
    Abstract:
    Pyrrole-imidazole polyamide ligands are highly sequence specific synthetic DNA-binding ligands that bind with high affinity. To counter the synthetic difficulties associated with coupling the electron-rich heterocyclic acids to the electron-deficient nucleophilic imidazole amine, a novel approach is described for synthesis of Fmoc-protected dimers for solid-phase peptide synthesis (SPPS). This method produces the dimers in high yields, is broadly applicable to other heterocyclic-containing polyamides, and results in improved ligand yields and synthesis times.
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