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  • Title: [The possible role of the salivary gland substrate in ixodid ticks as an adjuvant enhancing arbovirus transmission].
    Author: Alekseev AN, Chunikhin SP, Rukhkian MIa, Stefutkina LF.
    Journal: Med Parazitol (Mosk); 1991; (1):28-31. PubMed ID: 2067469.
    Abstract:
    Using a model: salivary glands of Dermacentor ticks--tick-borne encephalitis virus--guinea pig--D. marginatus ticks, it became possible to confirm the data of Jones et al. (1989) on the role of a substrate of Rhipicephalus appendiculatus glands as a strong enhancer of orthomyxovirus Togoto transmission during subcutaneous administration of a moderate virus dose to virus-resistant guinea pig. A tendency was only noticed towards better infectivity of ticks with the administration of sub- or supraoptimal virus doses together with the adjuvant (salivary gland substrate), as well as enhanced sensitivity of male individuals to a combination of virus with adjuvant. The latter fact can be explained by a transptyal way of infection typical for male individuals, which was noted earlier during joint nutrition with infected female individuals. A lower level of virus reproducibility in ticks who got it together with the adjuvant, as compared to the control, has been established. Low titer in female individuals after nutrition reduces the likelihood of transovarial transmission of virus with adjuvant.
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