These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Quantitative MAIPA: Comparison of different MAIPA protocols.
    Author: Killie MK, Salma W, Bertelsen E, Skogen B, Husebekk A.
    Journal: Transfus Apher Sci; 2010 Oct; 43(2):149-54. PubMed ID: 20675194.
    Abstract:
    INTRODUCTION: In a screening setting, maternal anti-HPA 1a antibody level has been found to be a good prognostic tool to identify newborns at risk for severe NAIT. AIM: Identify the optimal MAIPA protocol for quantitation of anti-HPA 1a antibodies. MATERIALS AND METHODS: Plasma were analysed for anti-HPA 1a antibodies using different monoclonal antibodies, lyophilized or fresh platelets and MAIPA protocols. RESULTS: The anti-HPA 1a antibody level varied significantly when different monoclonal antibodies were used. However, there was a strong correlation between maternal anti-HPA 1a antibody level and platelet count in the newborn. The sensitivity of the assay depended on the adopted MAIPA protocol. CONCLUSION: Consistent tests results are of importance for the clinical impact of the test.
    [Abstract] [Full Text] [Related] [New Search]