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  • Title: Surgical treatment in Paget's disease of the breast.
    Author: Siponen E, Hukkinen K, Heikkilä P, Joensuu H, Leidenius M.
    Journal: Am J Surg; 2010 Aug; 200(2):241-6. PubMed ID: 20678619.
    Abstract:
    BACKGROUND: The aim of this study was to evaluate the outcomes of surgical treatment of Paget's disease of the breast, with special emphasis on magnetic resonance imaging (MRI) and sentinel node biopsy (SNB). METHODS: The study included 58 consecutive patients with Paget's disease treated from 1995 to 2006. RESULTS: Twenty-five patients had ductal carcinoma in situ, and 31 had invasive carcinoma. MRI was performed in 14 patients, with positive findings in 7 patients, 5 of whom had negative findings on conventional imaging. The overall mastectomy rate was 76%. Eighteen patients underwent SNB, and 26 patients underwent full or partial axillary clearance. Fourteen patients had no axillary surgery. One patient had local recurrence after breast conservation, and another had axillary recurrence after negative results on SNB. Six patients had distant metastases. Four patients died of breast cancer. CONCLUSIONS: Paget's disease is frequently associated with peripheral or multicentric cancer. MRI may be helpful when considering breast conservation or omitting axillary nodal staging.
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