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  • Title: Boundary-lubricating ability and lubricin in synovial fluid of patients with temporomandibular joint disorders.
    Author: Wei L, Xiong H, Li B, Cheng Y, Long X.
    Journal: J Oral Maxillofac Surg; 2010 Oct; 68(10):2478-83. PubMed ID: 20678837.
    Abstract:
    PURPOSE: This study was conducted to measure the boundary-lubricating ability and lubricin concentration of synovial fluid (SF) from patients with different stages of temporomandibular joint disorders (TMDs) and establish relationships between them. PATIENTS AND METHODS: According to the imaging and clinical findings, TMD patients were divided into 3 subgroups: displaced disc with reduction, displaced disc without reduction, and osteoarthritis. The boundary-lubricating ability of SF was determined by the coefficient of friction (COF) of SF in vitro with a friction apparatus. The lubricin concentrations were quantified by enzyme-linked immunosorbent assays. RESULTS: The COF of SF in TMD patients was significantly higher than that of healthy control subjects, but no observed difference was found among patient subgroups. Furthermore, a significant decline in lubricin concentrations was found in the group with osteoarthritis, whereas there was no significant change in the other groups. However, a significant correlation was not found between the COF and the lubricin concentrations in our study. CONCLUSIONS: These findings showed that distinct changes in lubricin and boundary-lubricating ability in the SF occurred with different stages of TMDs.
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