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  • Title: [Formula screening and optimizing for the dispersible tablets of breviscapine by orthogonal experiment].
    Author: Ding Y, Huang GH.
    Journal: Zhong Yao Cai; 2010 Mar; 33(3):455-8. PubMed ID: 20681316.
    Abstract:
    OBJECTIVE: To establish a suitable formulation for the dispersible tablets of brevisicapine. METHODS: To prepare and optimize the breviscapine dispersible tablets by orthogonal experiment design using disintegration time as the index. The quality of breviscapine dispersible tablets was evaluated by the initial stability test. RESULTS: The disintegration time of optimized prescription formulation was 89 s. L-HPC and CMS-Na were used by combining exterior and interior and the dissolution percent in vitro was obviously superior to the conventional tablets, and the quality of the dispersible tablets was very good in stability test. CONCLUSION: The formulation screened out for the dispersible tablets of breviscapine is reasonable, stable and suitable for the production on a large scale.
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