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  • Title: Resolution of 2,2-disubstituted epoxides via biocatalytic azidolysis.
    Author: Molinaro C, Guilbault AA, Kosjek B.
    Journal: Org Lett; 2010 Sep 03; 12(17):3772-5. PubMed ID: 20681610.
    Abstract:
    A practical procedure for the enzymatic resolution of 2-alkyl-2-aryl-disubstituted epoxides using the Codex HHDH P2E2 enzyme and sodium azide is reported. This method allowed the synthesis of novel regio- and enantioselective 1-azido-2-arylpropan-2-ols in excellent yields. Furthermore, these intermediates were used for the preparation of enantiomerically enriched amino alcohols and aziridines containing a tertiary center.
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