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  • Title: Endoscopic retrograde cholangiopancreatography in the diagnosis and management of cholangiocarcinoma.
    Author: Coelho-Prabhu N, Baron TH.
    Journal: Clin Liver Dis; 2010 May; 14(2):333-48. PubMed ID: 20682239.
    Abstract:
    Cholangiocarcinomas (CCAs) are rare malignancies that arise from the biliary epithelium. Intrahepatic CCAs usually present as mass lesions that are asymptomatic or cause nonspecific systemic symptoms such as fatigue, fever, and weight loss. Hilar and extrahepatic tumors most commonly present with jaundice, though cholangitis also can be seen. Tumor markers such as carbohydrate antigen 19-9 and carcinoembryonic antigen have been used to diagnose CCA, but these are nonspecific and may be elevated in infection, inflammation, or any obstruction. Endoscopic retrograde cholangiopancreatography (ERCP) has been used for the diagnosis and management of CCA for many years. This article summarizes the data regarding the application of ERCP in the diagnosis and management of CCA.
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