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  • Title: MACC1 as a marker for advanced colorectal carcinoma.
    Author: Shirahata A, Shinmura K, Kitamura Y, Sakuraba K, Yokomizo K, Goto T, Mizukami H, Saito M, Ishibashi K, Kigawa G, Nemoto H, Hibi K.
    Journal: Anticancer Res; 2010 Jul; 30(7):2689-92. PubMed ID: 20682999.
    Abstract:
    BACKGROUND: Recently, Stein et al. identified the metastasis-associated in colon cancer 1 (MACC1) gene by genome-wide search for differentially expressed genes in human colon cancer tissues and metastases. PATIENTS AND METHODS: We analyzed MACC1 expression levels in 52 colorectal cancer samples using quantitative real-time polymerase chain reaction (QRT-PCR). RESULTS: We found that MACC1 expression showed significant correlation with peritoneal dissemination (p=0.042) and higher stage of TNM classification (p=0.007). CONCLUSION: These results suggest that MACC1 is more frequently expressed in advanced colorectal carcinomas.
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