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  • Title: [Effect of allopurinol on the indicators of immunity in podagra and experimental hyperuricemia].
    Author: Siniachenko OV, Nikolenko IuI, Diadyk AI, Bortnik VA, Okushko RV.
    Journal: Revmatologiia (Mosk); 1991; (1):12-5. PubMed ID: 2068454.
    Abstract:
    The authors studied the immunity indices in patients with gout against the background of a long-term (one year) therapy with allopurinol, and in animals with experimental hyperuricemia. During treatment the authors observed normalization of blood immunoglobulin M level, a considerable decrease in circulating immune complexes and anti-renal antibodies, a tendency to a rise in the function of T-lymphocytes, great enhancement of the activity of polymorphonuclear phagocytes in tests with Staphylococci and nitro-blue tetrazolium. Mechanisms of action of the given drug are discussed.
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