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  • Title: Determination of the G and P types of previously nontypeable rotavirus strains from the African Rotavirus Network, 1996-2004: Identification of unusual G types.
    Author: Esona MD, Steele D, Kerin T, Armah G, Peenze I, Geyer A, Page N, Nyangao J, Agbaya VA, Trabelsi A, Tsion B, Aminu M, Sebunya T, Dewar J, Glass R, Gentsch J.
    Journal: J Infect Dis; 2010 Sep 01; 202 Suppl():S49-54. PubMed ID: 20684717.
    Abstract:
    A total of 215 nontypeable rotavirus samples collected from children <5 years of age by members of the African Rotavirus Network were characterized using reverse-transcription polymerase chain reaction analysis and sequencing. The most predominant strain identified was P[8]G1 (46.9%). Genotypes P[8]G10, P[8]G8, P[6]G8, and P[7]G5 were also detected at frequencies varying from 0.5% to 2.3%. This study suggests that reassortment of unusual G types into a background of globally common genotype P[8] strains may be a major mechanism of generating rotavirus diversity. Nucleotide substitutions at the P[8], P[6], and G1 primer binding sites accounted for the failure to type these strains initially. Hence, these findings highlight the need for regular evaluation of rotavirus genotyping methods.
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