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Title: [Roflumilast: a new approach to therapy of chronic obstructive pulmonary disease]. Author: Kreutzkamp B. Journal: Med Monatsschr Pharm; 2010 Jul; 33(7):236-43. PubMed ID: 20687460. Abstract: Roflumilast, a new inhibitor of phosphodiesterase 4, showed moderate efficacy in clinical trials with patients suffering from chonic obstructive pulmonary disease (COPD). Improvement of pulmonary function is predominantly attributed to antiinflammatory effects with decrease in mucus secretion and less exacerbations. Diarrhoea, headache and nausea are typical adverse events.[Abstract] [Full Text] [Related] [New Search]