These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: A Pd-catalyzed approach to (1-->6)-linked C-glycosides.
    Author: Koester DC, Leibeling M, Neufeld R, Werz DB.
    Journal: Org Lett; 2010 Sep 03; 12(17):3934-7. PubMed ID: 20687593.
    Abstract:
    A flexible and robust method for the assembly of (1-->6)-linked C-glycosidic disaccharides is presented. The key reaction is a Pd-catalyzed coupling of 1-iodo- or 1-triflato-glycals with alkynyl glycosides. Reinstallation of the native hydroxyl group pattern is achieved after selective hydrogenation of the triple bond using Raney-nickel. Epoxidation with DMDO and reductive epoxide opening gives access to either the alpha- or the beta-derivative, depending on the hydride source.
    [Abstract] [Full Text] [Related] [New Search]