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  • Title: [Warfarin hipersensitivity: how to deal with it?].
    Author: Lima AF, Reis J, Serrano F, Borges A.
    Journal: Acta Med Port; 2010; 23(4):727-30. PubMed ID: 20688006.
    Abstract:
    The authors report a clinical case of warfarin hypersensitivity noticed when a patient, with thromboembolic risk, was submitted to warfarin. She was found to be heterozigotic to -1639G>A (gene VKORC1) and homozygotic to 1075A>C (genotype CYP2C9*3/*3). In this article the warfarin pharmacodinamics and its role over Vitamin K is revisited. It includes some suggested indications for investigating genetic polymorphisms, in order to avoid complications associated with warfarin.
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