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  • Title: AnalyzeNNLS: magnetic resonance multiexponential decay image analysis.
    Author: Bjarnason TA, Mitchell JR.
    Journal: J Magn Reson; 2010 Oct; 206(2):200-4. PubMed ID: 20688549.
    Abstract:
    Exponential decays are fundamental to magnetic resonance imaging, yet adequately sampling and analyzing multiexponential decays is rarely attempted. The advantage of multiexponential analysis is the quantification of sub-voxel structure caused by water compartmentalization, with application as a non-invasive imaging biomarker for myelin. We have developed AnalyzeNNLS, software designed specifically for multiexponential decay image analysis that has a user-friendly graphical user interface and can analyze data from many MR manufacturers. AnalyzeNNLS is a simple, platform independent analysis tool that was created using the extensive mathematical and visualization libraries in Matlab, and released as open source code allowing scientists to evaluate, scrutinize, improve, and expand.
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