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  • Title: Collaboration and competition between DNA double-strand break repair pathways.
    Author: Kass EM, Jasin M.
    Journal: FEBS Lett; 2010 Sep 10; 584(17):3703-8. PubMed ID: 20691183.
    Abstract:
    DNA double-strand breaks resulting from normal cellular processes including replication and exogenous sources such as ionizing radiation pose a serious risk to genome stability, and cells have evolved different mechanisms for their efficient repair. The two major pathways involved in the repair of double-strand breaks in eukaryotic cells are non-homologous end joining and homologous recombination. Numerous factors affect the decision to repair a double-strand break via these pathways, and accumulating evidence suggests these major repair pathways both cooperate and compete with each other at double-strand break sites to facilitate efficient repair and promote genomic integrity.
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