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  • Title: Up-regulation of angiotensin-converting enzyme and angiotensin II type 1 receptor in irradiated rats.
    Author: Ferreira-Machado SC, Rocha Nde N, Mencalha AL, De Melo LD, Salata C, Ribeiro AF, Torres Tda S, Mandarim-De-Lacerda CA, Canary PC, Peregrino AA, Magalhães LA, Cabral-Neto JB, Dealmeida CE.
    Journal: Int J Radiat Biol; 2010 Oct; 86(10):880-7. PubMed ID: 20695764.
    Abstract:
    PURPOSE: To investigate changes in cardiac functional parameters and the cardiac expression of angiotensin-converting enzyme (ACE), angiotensin II type 1 receptor (AT1), procollagen type I (proc-I) and transforming growth factor-ß1 (TGF-ß1) in rats irradiated at heart. MATERIAL AND METHODS: Male Wistar rats were irradiated with a single dose of radiation (0, 5, 10 and 15 Gray [Gy]) delivered directly to the heart and the molecular evaluations were performed at various times post-irradiation (two days, 15 days and four months). The expression of ACE, AT1, proc-I and TGF-ß1 were analysed using Real Time-Polymerase Chain Reaction (RT-PCR) and/or Western blotting. Cardiac structural and functional alterations were investigated at the four-month time point by echocardiography and by quantitative methods (stereology). RESULTS: Rats irradiated with 15 Gy showed a modest reduction in the ejection fraction. Cardiac proc-I, TGF-ß1, ACE and AT1 were also measurably increased. CONCLUSIONS: Irradiated rat hearts show simultaneous elevations in renin-angiotensin system components AT1 and ACE and cardiac remodeling markers proc-I and TGF-ß1.
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