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  • Title: Highly efficient and expedient synthesis of 5-hydroxy-1H-pyrrol-2-(5H)-ones from FeCl3-catalyzed tandem intramolecular enaminic addition of tertiary enamides to ketones and 1,3-hydroxy rearrangement.
    Author: Yang L, Lei CH, Wang DX, Huang ZT, Wang MX.
    Journal: Org Lett; 2010 Sep 03; 12(17):3918-21. PubMed ID: 20698503.
    Abstract:
    Catalyzed by FeCl(3) under very mild conditions, tertiary enamides underwent a highly efficient intramolecular enaminic addition reaction to the ketonic carbonyls followed by 1,3-hydroxy rearrangement to produce 5-hydroxy-1H-pyrrol-2(5H)-ones in excellent yields.
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